Related Experiment Video

Updated: Jun 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Dysregulation of circular RNAs in inflammation and cancers

Jiayu Liu1,2, Fangqing Zhao3,4,5,6, Ling-Ling Chen7,8,6

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

Fundamental Research
|June 27, 2024
PubMed

Insights

Circular RNAs are regulated molecules, not splicing errors. Their dysregulation is linked to diseases like cancer, offering potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Disease Pathogenesis

Background:

  • Circular RNAs (circRNAs) are increasingly recognized as functional molecules, not merely splicing byproducts.
  • Their biogenesis, turnover, and cellular localization are tightly regulated processes.
  • Aberrant circRNA expression is implicated in various disease states.

Purpose of the Study:

  • To review the role of circular RNAs in disease progression.
  • To focus on the link between circRNA dysregulation, metaflammation, and cancer.
  • To discuss therapeutic strategies targeting disease-related circRNAs.

Main Methods:

  • Literature review of studies on circular RNA biogenesis, function, and disease association.
  • Analysis of circRNA expression patterns in different cell types and tissues.
  • Examination of the link between circRNA dysregulation and pathological processes like metaflammation and cancer.

Main Results:

  • Circular RNA production is a regulated process with specific biogenesis and turnover mechanisms.
  • circRNAs exhibit cell type- and tissue-specific expression and subcellular localization.
  • Dysregulated circRNAs are associated with the pathogenesis and progression of diseases, including metaflammation and cancers.

Conclusions:

  • Aberrant circular RNA biogenesis, localization, and degradation contribute to disease progression.
  • Targeting disease-related circular RNAs presents potential therapeutic avenues.
  • Obstacles in targeting circRNAs for therapeutic purposes need to be addressed.
Keywords:
BiogenesisCircular RNADegradationMetaflammationSubcellular localization

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