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Updated: Sep 16, 2026

Biochemical Titration of Glycogen In vitro
Published on: November 24, 2013
Lysosomal glycogen storage induced by Acarbose, a 1,4-alpha-glucosidase inhibitor
Abstract:
The 1,4-alpha-glucosidase inhibitor. Acarbose, when injected intraperitoneally disturbs liver lysosome metabolism, causing distinct and persistent inhibition of the enzymes and acute disturbances of lysosomal glycogen metabolism. A feedback control mechanism appears to operate, affecting cytosolic carbohydrate metabolism. A model is suggested for the adult form of lysosomal storage disease. The biochemical effects closely resemble those occurring in glycogenosis type II (Pompe's disease), and these have been confirmed by electron microscopy.
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