Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

27.3K
Overview
27.3K
Hypersensitivities01:30

Hypersensitivities

580
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
580
Antibody Structure01:10

Antibody Structure

59.9K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
59.9K
Cross-reactivity00:42

Cross-reactivity

31.0K
Overview
31.0K
Allergic Drug Reactions01:27

Allergic Drug Reactions

832
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
832
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

483
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
483

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial resistance in paediatric bloodstream infections in Tanzania: a longitudinal comparison of two cohort studies.

BMC microbiology·2026
Same author

Examining implementation of the first risk stratification-based programme for evaluating penicillin allergy labels in Western Norway hospitals: a study protocol.

BMJ open·2025
Same author

Norwegian Anaesthesiologist's Perspectives on Perioperative Allergies and Penicillin Allergy Evaluations: A National Survey.

Acta anaesthesiologica Scandinavica·2025
Same author

Diagnostic delay in patients diagnosed with Lyme carditis presenting with cardiac symptoms.

Journal of cardiology cases·2025
Same author

"What if the patient has a severe reaction, and it is my fault?" A qualitative study exploring factors for sustainable implementation of penicillin allergy delabelling.

Antimicrobial resistance and infection control·2024
Same author

Serum mast cell tryptase reference intervals in European populations.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2023

Related Experiment Video

Updated: Jun 22, 2025

Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
07:01

Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules

Published on: September 16, 2022

1.7K

Anaphylaxis triggered by alpha-gal allergy.

Synne Dragesund Rørvik1, Marie Bjørbak Alnæs2, Bjørn-Christian Vikenes3

  • 1Hjerteavdelingen, Haukeland universitetssjukehus.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Alpha-gal syndrome, a red meat allergy, is triggered by tick bites. Diagnosis involves identifying alpha-gal IgE antibodies, leading to dietary changes to avoid allergic reactions.

More Related Videos

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.4K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.4K

Related Experiment Videos

Last Updated: Jun 22, 2025

Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
07:01

Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules

Published on: September 16, 2022

1.7K
Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.4K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.4K

Area of Science:

  • Allergology
  • Immunology

Background:

  • Alpha-gal syndrome is a rare allergy linked to tick bites and mammalian meat consumption.
  • Sensitization occurs via tick saliva, leading to IgE antibody production against alpha-gal.

Observation:

  • A case presentation of a man in his sixties experiencing acute anaphylaxis.
  • History included multiple tick bites and recent mammalian meat intake, suggesting alpha-gal syndrome.

Findings:

  • Diagnosis confirmed by elevated alpha-gal IgE antibodies and clinical assessment.
  • The patient received dietary instructions to avoid alpha-gal-containing foods and products.

Implications:

  • Highlights the importance of recognizing alpha-gal syndrome in patients with anaphylaxis and tick exposure history.
  • Emphasizes the need for strict dietary management to prevent future allergic reactions and anaphylaxis.