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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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[Sleep disorders and oncological diseases].

O V Kolokolov1, E A Salina1, O I Lvova1

  • 1Razumovsky Saratov State Medical University, Saratov, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Cancer patients often experience insomnia due to various factors, including antitumor therapy and immune system dysfunction. Addressing sleep disturbances is crucial for improving patient prognosis and overall health.

Keywords:
cancerdepressioninsomniamelatoninobstructive sleep apneasleep disorders

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Area of Science:

  • Neurology
  • Oncology
  • Sleep Medicine

Background:

  • Cancer prevalence is increasing, alongside a rise in insomnia, exacerbated by factors like the COVID-19 pandemic.
  • Sleep disorders are recognized as a negative prognostic factor in cancer patients.
  • Neurological symptoms associated with neoplasms and their treatments require thorough investigation.

Purpose of the Study:

  • To review the risk factors and mechanisms of sleep disturbances in cancer patients.
  • To explore the relationship between sleep disorders, inflammation, and immune system dysfunction in cancer.
  • To highlight the role of the melatonergic system in insomnia and cancer development.

Main Methods:

  • Literature review focusing on neurological aspects of cancer and antitumor therapy.
  • Analysis of studies investigating sleep disturbances in oncological patients.
  • Examination of the interplay between the immune system, inflammation, and sleep.

Main Results:

  • Sleep disturbances are linked to increased inflammation and immune dysfunction in cancer.
  • Melatonergic system dysfunction is identified as a significant risk factor for both insomnia and cancer.
  • Neurological symptoms in cancer patients are often associated with sleep issues.

Conclusions:

  • Restoring normal sleep patterns is essential for the mental and physical rehabilitation of cancer patients.
  • Understanding the mechanisms of sleep disturbance in cancer can inform targeted therapeutic interventions.
  • Further research into the melatonergic system's role may lead to novel strategies for managing cancer-related insomnia.