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Updated: Jun 22, 2025
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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A Dual-Armed Oncolytic Virus Shows Clinical Efficacy in Advanced Solid Cancers
Noelia Silva-Pilipich1,2, Cristian Smerdou1,2
1Division of DNA and RNA Medicine, CCUN, Pamplona, Spain.
Abstract:
An oncolytic adenovirus armed with tumor necrosis factor-α and interleukin-2 was tested in patients with advanced solid tumors. Antitumor effects were observed in both treated and non-treated lesions, leading to long-term survival in some patients. This clinical trial shows the potential of oncolytic virotherapy for patients refractory to standard therapies. See related article by Pakola et al., p. 3715.
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