Related Experiment Video
Updated: Jul 16, 2026
11:50
Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
Published on: April 10, 2012
Normal human granulopoiesis revisited. II. Bone marrow data.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1985
Summary
This study reviews human bone marrow neutrophil data to describe granulopoiesis kinetics. It provides reference data for neutrophil production and estimates ineffective bone marrow production.
Area of Science:
- Hematology
- Cell Biology
- Kinetics
Background:
- Previous work detailed methods for studying neutrophil granulocyte lineage kinetics.
- Established reference data for circulating granulocyte half-life, pool size, and turnover.
Purpose of the Study:
- To review and discuss human bone marrow neutrophil data.
- To establish reference data for neutrophil production kinetics within the bone marrow.
- To provide a comprehensive kinetic description of granulopoiesis.
Main Methods:
- Review of existing human bone marrow neutrophil data.
- Analysis of cellularity, mitotic activity, and cell kinetics.
- Discussion of differential cell counts and production parameters.
Main Results:
- Reference data for bone marrow neutrophil kinetics were established.
- Challenges in bone marrow differential cell counts were identified.
- A coherent kinetic model for granulopoiesis was developed.
Conclusions:
- Human bone marrow neutrophil kinetics are now better defined.
- The study quantifies ineffective bone marrow production.
- Provides a comprehensive kinetic description of granulopoiesis.
Related Concept Videos
01:21Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
01:19Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
01:20Overview of Hematopoiesis
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...