Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential Impact of the OPTN Status Escalation Policy for Adult Heart Transplant Candidates With Durable LVADs.

Circulation. Heart failure·2026
Same author

Evaluation of SOFA-2 Score Performance Across Demographic Subgroups: An External Validation Study Using MIMIC-IV.

medRxiv : the preprint server for health sciences·2026
Same author

Cardiovascular pharmacotherapy in 2025.

European heart journal. Cardiovascular pharmacotherapy·2026
Same author

Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress.

Nature communications·2026
Same author

Association between listing hemodynamics and heart transplantation waitlist outcomes: An analysis of the Scientific Registry of Transplant Recipients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2025
Same author

European Journal of Heart Failure consensus statement. Heart failure pharmacotherapy for patients with heart failure with reduced ejection fraction and concomitant atrial fibrillation: Review of evidence and call to action.

European journal of heart failure·2025
Same journal

The Political Determinants of Obstetric Prescribing.

Obstetrics and gynecology·2026
Same journal

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes: A Systematic Review and Meta-analysis.

Obstetrics and gynecology·2026
Same journal

Milestones in Motion: Vaginal Birth After Cesarean.

Obstetrics and gynecology·2026
Same journal

Ebola Virus in Pregnancy.

Obstetrics and gynecology·2026
Same journal

A Quality-Improvement Study Evaluating Three Postpartum Prophylactic Oxytocin Rates and Blood Loss After Vaginal Birth.

Obstetrics and gynecology·2026
Same journal

The Effects of Climate Change on Obstetric and Gynecologic Health.

Obstetrics and gynecology·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2025

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation
05:46

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation

Published on: January 17, 2019

10.0K

Intramural Leiomyomas and Fertility: A Systematic Review and Meta-Analysis.

Taïna Laurore Pritts1, Meghan Ogden, William Parker

  • 1University of Wisconsin and the Wisconsin Fertility Institute, Madison, Wisconsin; and the University of California, San Diego, San Diego, and Advanced Fertility Associates Medical Group, Santa Rosa, California.

Obstetrics and Gynecology
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Even small intramural leiomyomas reduce fertility, and their removal offers no benefit. Multiple leiomyomas also significantly decrease pregnancy and live-birth rates in women.

More Related Videos

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
11:29

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

Published on: January 22, 2022

14.1K
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:13

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

809

Related Experiment Videos

Last Updated: Jun 22, 2025

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation
05:46

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation

Published on: January 17, 2019

10.0K
Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
11:29

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

Published on: January 22, 2022

14.1K
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
08:13

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

809

Area of Science:

  • Reproductive Medicine
  • Gynecologic Surgery
  • Infertility Research

Background:

  • Intramural leiomyomas are common uterine fibroids that can impact fertility.
  • The relationship between leiomyoma size, number, and fertility outcomes requires further clarification.

Purpose of the Study:

  • To evaluate fertility outcomes based on the size and number of intramural leiomyomas.
  • To assess the impact of myomectomy on fertility outcomes in women with intramural leiomyomas.

Main Methods:

  • Systematic literature search of MEDLINE, ClinicalTrials.gov, PubMed, Cochrane Library, and PROSPERO (1994-2023).
  • Inclusion of 13 study groups from 5,143 identified studies.
  • Analysis of clinical pregnancy rates and ongoing pregnancy or live-birth rates.

Main Results:

  • Smaller intramural leiomyomas (<3 cm and 3-6 cm) were associated with significantly lower clinical pregnancy and live-birth rates compared to women without leiomyomas.
  • In datasets without size exclusion, leiomyomas <5 cm showed reduced clinical pregnancy rates, while larger leiomyomas (>5 cm) showed no significant difference.
  • Women with multiple leiomyomas had significantly lower clinical pregnancy and live-birth rates compared to those with a single leiomyoma.
  • Myomectomy for intramural leiomyomas did not demonstrate a significant difference in clinical pregnancy rates compared to leiomyomas in situ.

Conclusions:

  • Intramural leiomyomas, even small ones, are linked to reduced fertility.
  • Surgical removal (myomectomy) of intramural leiomyomas does not appear to improve fertility outcomes.
  • The presence of multiple leiomyomas is associated with diminished fertility potential.