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Common human leucocyte antigensassociated with the development of subacute thyroiditis and COVID-19

  • 0Ankara University, Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism, Ankara, Türkiye.
Human Immunology +

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June 27, 2024

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June 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Human leucocyte antigen (HLA) alleles may influence susceptibility to coronavirus disease-19 (COVID-19) and subsequent subacute thyroiditis (SAT). Specific HLA types were associated with differing risks for COVID-19 and post-COVID-19 SAT.

Area Of Science

  • Immunogenetics
  • Endocrinology
  • Infectious Diseases

Background

  • Subacute thyroiditis (SAT) has been reported following coronavirus disease-19 (COVID-19).
  • Human leucocyte antigen (HLA) alleles are known to be associated with SAT.
  • Understanding the genetic predisposition to COVID-19 and post-infectious SAT is crucial.

Purpose Of The Study

  • To identify specific HLA alleles that may predispose individuals to COVID-19 infection.
  • To determine HLA alleles associated with the development of post-COVID-19 subacute thyroiditis.
  • To investigate the relationship between HLA genotypes and susceptibility to COVID-19 and SAT.

Main Methods

  • A retrospective study involving 51 patients with SAT and 190 healthy bone marrow donors.
  • Genotyping of HLA-A, -B, -C, -DRB1, and -DQB1 using next-generation sequencing.
  • Stratification of participants into four groups based on SAT and COVID-19 status.

Main Results

  • HLA-DQB1*04:02 was less frequent in COVID-19 positive individuals, suggesting a protective effect against infection.
  • Specific HLA alleles (HLA-B*35:01, HLA-B*35:03, HLA-DRB1*12:01, HLA-DRB1*14:01) showed different frequencies in SAT(+) vs. SAT(-) individuals without COVID-19.
  • Distinct HLA alleles (HLA-C*12:03, HLA-DQB1*06:04, HLA-DRB1*13:02, HLA-DRB1*13:03) were associated with SAT in COVID-19 positive individuals.

Conclusions

  • The study identified specific human leucocyte antigen (HLA) alleles associated with susceptibility to subacute thyroiditis (SAT).
  • The identified HLA alleles and their association with SAT appear to be influenced by the history of coronavirus disease-19 (COVID-19) infection.
  • Genetic factors, specifically HLA types, play a role in the risk of developing COVID-19 and subsequent SAT.

Keywords:

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