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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Psychoneuroimmunology: Cardiovascular Disease01:27

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prospective Cardiovascular Events In Patients With Advanced Thoracic Cancer Treated With Immune Checkpoint Inhibitor.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prospective Cardiovascular Events In Patients With Advanced Thoracic Cancer Treated With Immune Checkpoint Inhibitor.

Related Experiment Video

Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Prospective cardiovascular events in patients with advanced thoracic cancer treated with immune checkpoint inhibitor.

Anne-Claire Toublanc1, Maxime Faure2, Guillaume Verdy3

  • 1Pulmonary Department, CIC1401, CHU Haut-Lévèque, Bordeaux, France.

European Journal of Cancer (Oxford, England : 1990)
|June 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Systematic screening for immune-related myocarditis in advanced lung cancer patients detected a 1.68% incidence, all asymptomatic. This approach also identified other cardiovascular diseases, aiding early management in this high-risk population.

Keywords:
Immune checkpoint inhibitorsMajor cardiovascular eventsMyocarditisScreening

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Area of Science:

  • Cardiology
  • Oncology
  • Immunology

Background:

  • Immune-related myocarditis is a rare but severe adverse event associated with immune checkpoint inhibitors (ICIs).
  • Early detection and management are crucial for improving patient outcomes.
  • Advanced lung cancer patients receiving ICIs represent a population at risk for cardiovascular complications.

Purpose of the Study:

  • To prospectively evaluate the incidence of immune-induced myocarditis in advanced lung cancer patients treated with ICIs.
  • To assess the impact of systematic troponin screening for early detection of myocarditis and other major adverse cardiovascular events (MACE).
  • To investigate the clinical characteristics and outcomes of immune-induced myocarditis.

Main Methods:

  • A prospective, bicentric study included 298 adult patients receiving ICIs for advanced lung cancer.
Troponin
lung cancer
  • Baseline cardiac biomarkers, ECG, and transthoracic echocardiography were performed.
  • Myocarditis diagnosis followed European Society of Cardiology guidelines; MACEs were recorded.

    • Main Results:

    • Five cases (1.68%) of immune-induced myocarditis were identified, all asymptomatic and detected via troponin elevation.
    • No deaths were directly attributed to myocarditis; treatment involved corticosteroids and ICI discontinuation.
    • Systematic screening also detected 14 other cardiovascular diseases and 11 MACEs during ICI therapy.

    Conclusions:

    • Systematic cardiovascular screening identified a slightly higher incidence of subclinical immune-induced myocarditis than previously reported.
    • Screening did not alter treatment strategies due to the asymptomatic nature of detected cases.
    • This screening approach is valuable for detecting other cardiovascular diseases in patients receiving ICIs for advanced lung cancer.