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Updated: Jun 22, 2025

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Nonlocal structural effects of water on DNA homology recognition
Ehud Haimov1, Jonathan G Hedley1, Alexei A Kornyshev1
1Department of Chemistry, Faculty of Natural Sciences, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane W12 0BZ, United Kingdom.
Abstract:
The mechanism behind mutual recognition of homologous DNA sequences prior to genetic recombination is one of the remaining puzzles in molecular biology. Leading models of homology recognition, based on classical electrostatics, neglect the short-range nonlocal screening effects arising from structured water around DNA, and hence may only provide insight for relatively large separations between interacting DNAs. We elucidate the role of the effects of the nonlocal dielectric response of water on DNA-DNA interaction and show that these can dramatically enhance the driving force for recognition.
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