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Updated: Jun 22, 2025
02:09
Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
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Mass spectrometry imaging in pulmonary disorders
1Key Laboratory of Environment Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China.
Summary
Mass Spectrometry Imaging (MSI) offers detailed in situ tissue analysis for pulmonary disorders and drug studies. This technology aids in adjunct diagnosis, biomarker discovery, and understanding drug distribution in lung tissues.
Area of Science:
- Analytical Chemistry
- Biomedical Imaging
- Pharmacology
Background:
- Mass Spectrometry Imaging (MSI) is an advanced technique for in situ tissue analysis.
- It provides detailed chemical and spatial distribution data of endogenous and exogenous compounds.
- Existing analytical methods do not offer the same comprehensive insights.
Purpose of the Study:
- To review the principles and applications of MSI in pulmonary medicine.
- To highlight MSI's role in diagnosing lung disorders and discovering biomarkers.
- To discuss MSI's utility in investigating drug distribution dynamics.
Main Methods:
- Review of current scholarly literature on Mass Spectrometry Imaging.
- Analysis of MSI's capabilities in chemical characterization and spatial mapping.
- Examination of MSI's application in pulmonary disease research and pharmacology.
Main Results:
- MSI enables unparalleled in situ characterization of tissue chemical landscapes.
- It is increasingly utilized for adjunct diagnosis and biomarker research in pulmonary disorders, including lung cancer.
- MSI effectively elucidates the spatiotemporal dynamics of pharmacological agents.
Conclusions:
- MSI is a powerful tool for in situ tissue analysis with significant applications in pulmonary medicine.
- Its role in diagnosis, biomarker discovery, and drug distribution studies is expanding.
- Future advancements in MSI technology promise further innovation in biomedical research.
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