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Golgi apparatus targeted therapy in cancer: Are we there yet?

Zheng Yang Lee1, Wen Hwei Lee1, Jing Sheng Lim1

  • 1School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500 Subang Jaya, Selangor, Malaysia.

Life Sciences
|June 27, 2024
PubMed

Insights

Cancer cells exploit Golgi apparatus defects for growth and spread. This review details abnormal Golgi genes in cancer and emerging Golgi-targeting drugs, highlighting the need for further development to treat patients.

Area of Science:

  • Cell Biology
  • Oncology
  • Molecular Medicine

Background:

  • Membrane trafficking in the Golgi apparatus is crucial for protein and lipid transport.
  • Dysregulated Golgi trafficking is implicated in cancer progression, aiding processes like proliferation and metastasis.
  • Current therapeutic strategies lack specific drugs targeting Golgi apparatus manipulation in cancer.

Purpose of the Study:

  • To delineate abnormal Golgi genes and proteins involved in carcinogenesis.
  • To examine the impact of genetic variations on Golgi functions including trafficking, glycosylation, and pH.
  • To provide an update on Golgi apparatus-targeted inhibitors in clinical trials for cancer therapy.

Main Methods:

  • Comprehensive literature review of studies on Golgi apparatus and cancer.
  • Analysis of molecular signaling pathways associated with Golgi abnormalities.
  • Survey of preclinical and clinical data for Golgi-targeted inhibitors.

Main Results:

  • Identified specific abnormal Golgi genes and proteins contributing to cancer development.
  • Detailed the functional consequences of Golgi variations on cellular processes.
  • Cataloged promising Golgi apparatus-targeted inhibitors currently in development.

Conclusions:

  • Aberrant Golgi trafficking is a key feature exploited by cancer cells.
  • Targeting the Golgi apparatus presents a promising, yet underdeveloped, therapeutic avenue.
  • Further research and development are essential to translate Golgi-targeted inhibitors into effective cancer treatments.
Keywords:
CancerEndoplasmic reticulumGene expressionGlycosylationGolgi apparatus

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