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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Scrotal Cancer Incidence Rates and Trends-United States, 1999-2020.

Jacqueline M Mix1, Sameer V Gopalani1, Maureen Miller2

  • 1Centers for Disease Control and Prevention, Atlanta, GA; Oak Ridge Institute for Science and Education, Oak Ridge, TN.

Urology
|June 27, 2024
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Summary
This summary is machine-generated.

Scrotal cancer incidence in US men remains low but was higher than previously reported. Rates varied by age and race, with some subtypes showing significant trends over time.

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Area of Science:

  • Oncology
  • Epidemiology
  • Urologic Oncology

Background:

  • Scrotal cancer is a rare malignancy in men.
  • Understanding population-level incidence and trends is crucial for public health surveillance.

Purpose of the Study:

  • To examine scrotal cancer incidence rates and trends in adult men in the United States from 1999 to 2020.

Main Methods:

  • Utilized data from the United States Cancer Statistics (covering ~96% of the US population).
  • Calculated age-standardized incidence rates for men aged 18+.
  • Analyzed trends by age, race/ethnicity, region, and histology using joinpoint regression.

Main Results:

  • Identified 4669 cases of scrotal cancer (0.20 per 100,000).
  • Highest incidence observed in men aged 70+ (0.82 per 100,000).
  • Non-Hispanic Asian or Pacific Islander men had higher rates (0.31 per 100,000).
  • Squamous cell carcinoma, extramammary Paget disease, and sarcoma were the most common subtypes.
  • Incidence decreased for non-Hispanic Asian/Pacific Islander men and basal cell carcinomas, while increasing for extramammary Paget disease.

Conclusions:

  • Scrotal cancer incidence rates, while higher than previously reported, remain low overall.
  • Rates demonstrated stability over the study period for most demographic and histologic groups.