Stratified medicine for acute and chronic coronary syndromes: A patient-tailored approach

Area of Science:

• Cardiovascular Medicine
• Genomics and Precision Health

Background:

• Traditional cardiovascular disease management uses uniform treatment pathways based on symptoms.
• This "one-size-fits-all" approach may not optimize outcomes for all patients.
• The need for personalized treatment strategies is increasingly recognized.

Purpose of the Study:

• To review strategies for applying stratified management in acute and chronic coronary syndromes.
• To explore the integration of multi-omics data with traditional clinical information for precision medicine.
• To highlight the role of biomarkers and intravascular assessment in identifying distinct endotypes.

Main Methods:

• Review of current literature on precision medicine in cardiology.
• Discussion of multi-omics technologies and their application in identifying disease endotypes.
• Analysis of biomarkers and intravascular assessment techniques for patient stratification.

Main Results:

• Biomarkers and intravascular assessments can differentiate endotypes within ischemic heart disease.
• These endotypes exhibit distinct pathophysiologies, suggesting varied treatment responses.
• Stratified management holds promise for optimizing treatment in coronary syndromes.

Conclusions:

• Precision medicine offers a paradigm shift from uniform to tailored cardiovascular care.
• Identifying patient endotypes is crucial for effective stratified management of coronary syndromes.
• Integrating diverse data sources, including multi-omics, is key to advancing precision cardiology.