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Related Experiment Video

Updated: Jun 22, 2025

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
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Prostate-Specific Membrane Antigen-Targeted Imaging and Its Correlation with HOXB13 Expression.

Duminduni Hewa Angappulige1, Nimrod S Barashi1, Nicholas Pickersgill1

  • 1Division of Urologic Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Homeobox 13 (HOXB13) oncogene correlates with prostate-specific membrane antigen (PSMA) expression and PSMA PET imaging. This suggests PSMA PET may serve as a biomarker for aggressive prostate cancer (PC) driven by HOXB13.

Keywords:
HOXB13PSMAPSMA PETandrogen receptormetastasisprostate cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Radiology

Background:

  • Homeobox 13 (HOXB13) is an oncogenic transcription factor implicated in prostate cancer (PC) progression.
  • HOXB13 regulates prostate-specific membrane antigen (PSMA) expression and promotes resistance to androgen receptor (AR)-targeted therapies.
  • PSMA is a key target for PET imaging in PC.

Purpose of the Study:

  • To investigate the correlation between HOXB13 expression and PSMA PET imaging findings in prostate cancer patients.
  • To determine if PSMA PET standardized uptake values (SUVs) reflect HOXB13 transcriptional activity.

Main Methods:

  • Analysis of two independent prostate cancer patient cohorts undergoing PSMA PET/CT imaging.
  • Examination of HOXB13, PSMA, and AR mRNA and protein expression in tumor samples.
  • Correlation and association analyses between HOXB13 levels, PSMA expression, and PSMA PET SUVs.

Main Results:

  • A significant correlation was observed between HOXB13 and PSMA mRNA expression (P < 0.01).
  • PSMA PET SUVs (SUVmax, SUVpeak) showed a significant association with HOXB13 expression at both mRNA and protein levels.
  • Treatment-naïve patients with lymph node metastases had elevated HOXB13 and PSMA levels, higher PSMA uptake, and low AR expression.

Conclusions:

  • HOXB13 expression correlates with PSMA expression and PSMA PET SUVs.
  • PSMA PET findings may indicate oncogenic HOXB13 activity in prostate cancer.
  • PSMA PET could potentially serve as an imaging biomarker for more aggressive prostate cancer.