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Updated: Jun 22, 2025
Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
Published on: December 14, 2019
"Quality of life is impaired in children with chronic pancreatitis: A multicenter study"
Ankit Agrawal1, Anshu Srivastava1, Prabhakar Mishra2
1Departments of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Insights
Children with chronic pancreatitis (CP) experience significantly reduced quality of life (QOL), particularly in physical and psychosocial aspects. Pain and lower socioeconomic status (SES) are key factors impacting QOL in pediatric CP patients.
Area of Science:
- Pediatric Gastroenterology
- Quality of Life Research
- Child Health Outcomes
Background:
- The impact of chronic pancreatitis (CP) on children's quality of life (QOL) is not well-documented.
- Understanding these effects is crucial for improving care for pediatric CP patients.
Purpose of the Study:
- To evaluate the QOL in children with CP in India.
- To identify factors contributing to QOL impairment.
- To determine the prevalence of anxiety and depression in this population.
Main Methods:
- Prospective enrollment of 121 children (8-18 years) with CP across three Indian pediatric gastroenterology centers.
- QOL assessed using the PedsQL 4.0 scale (child and parent-reported).
- Anxiety and depression evaluated using the RCADS 25 scale; contributing factors analyzed via logistic regression.
Main Results:
- Children with CP exhibited significantly poorer QOL compared to healthy controls (74.6 ± 16 vs. 87.5 ± 11.1, p < 0.0001).
- Pain and lower socioeconomic status (SES) were associated with reduced physical and psychosocial QOL.
- Girls reported poorer psychosocial QOL than boys (OR 3.1); anxiety and depression were uncommon (1.6%).
Conclusions:
- Pediatric patients with CP experience impaired physical and psychosocial QOL.
- Pain and lower SES are significant adverse determinants of QOL in children with CP.
- Psychiatric comorbidities like anxiety and depression appear uncommon in this cohort.
Background And Objectives:
The impact of chronic pancreatitis (CP) on quality of life (QOL) of children is not well established. Our objective was to evaluate the QOL, identify contributing factors, and determine the prevalence of anxiety and depression in children with CP in India.
Methods:
Children (8-18y old) with CP were prospectively enrolled across three pediatric gastroenterology centres in India. QOL was assessed using the pediatric QOL inventory (PedsQL 4.0) scale, administered to both children and their parents. Anxiety and depression was studied using the Revised Children's Anxiety and Depression Scale (RCADS 25). Contributing factors were identified using binary logistic regression analysis. The data was compared against published QOL data in healthy Indian children.
Results:
121 children with CP (boys-57.9 %, age at QOL-14 ± 3.2years) were enrolled. A majority (82.7 %) had pain and advanced disease (Cambridge grade IV- 63.6 %). Children with CP had poorer QOL compared to controls (total score 74.6 ± 16 vs. 87.5 ± 11.1, p < 0.0001). QOL scores were similar across centres. Older children were similar to younger ones, except for a poorer emotional QOL. Taking QOL < -2 standard deviation (SD) of controls, ∼35 % had poor physical (50.9 ± 11.9) and 20 % had poor psychosocial (PS) QOL score (52.1 ± 7.2). On analysis, presence of pain and lower socio-economic status (SES) adversely affected both physical and PS-QOL. Additionally, girls had poorer PS-QOL than boys (Odds ratio 3.1, 95%CI:1.23-7.31). Anxiety and depression were uncommon (2,1.6 %).
Conclusions:
Patients with CP had impaired physical and psycho-social QOL. Presence of pain and lower SES adversely affected QOL. Psychiatric comorbidities were uncommon.
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