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Related Experiment Video

Updated: Jun 25, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Should systematic prostatic biopsies be discontinued?

Laurence Klotz¹

¹University of Toronto, Sunnybrook Chair of Prostate Cancer Research, Sunnybrook Health Sciences Centre, 2075 Bayview Ave MG 408, Toronto, ON, M4N3M5, Canada. Laurence.Klotz@Sunnybrook.ca.

Prostate Cancer and Prostatic Diseases

|June 27, 2024

Summary

Systematic biopsies may miss significant prostate cancers, but invisible lesions are often indolent. Monitoring with MRI and targeted biopsies is preferred over systematic biopsies for better patient outcomes.

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Area of Science:

Urology
Oncology
Medical Imaging

Background:

Systematic biopsies are used alongside targeted biopsies due to a 15-20% miss rate for clinically significant cancers.
Concerns about missed cancers influence interventions like systematic biopsies and preference for whole-gland treatment.

Purpose of the Study:

To review genomic and clinical data on MRI-invisible prostate lesions.
To evaluate the clinical significance and genomic profile of MRI-invisible prostate cancers.

Main Methods:

Review of recent genomic and clinical studies.
Analysis of data linking genetic aberrations to cancer visibility, invasiveness, and metastasis.

Main Results:

MRI-invisible prostate lesions, despite "clinically significant" histology, are genomically and clinically favorable.
Genetic aberrations driving cancer visibility are also linked to invasiveness; invisible cancers are typically indolent.

Conclusions:

Systematic biopsies can be abandoned for most patients.
Monitoring with imaging and repeat targeted biopsies for MRI progression is a preferred strategy with patient benefits.