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Updated: Jun 22, 2025

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Correction: H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2

Eunbi Lee1,2,3, Yoon Jung Park2,3, Anders M Lindroth4

  • 1Graduate School of Cancer Science and Policy, Cancer Biomedical Science, National Cancer Center, Goyang-si, Republic of Korea.

Cancer Gene Therapy
|June 27, 2024
PubMed
Abstract

No abstract available in PubMed .

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
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