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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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  9. Predictive And Prognostic Markers
  11. Cthrc1 Is A Prognostic Biomarker Correlated With Immune Infiltration In Head And Neck Squamous Cell Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Cthrc1 Is A Prognostic Biomarker Correlated With Immune Infiltration In Head And Neck Squamous Cell Carcinoma.

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CTHRC1 is a prognostic biomarker correlated with immune infiltration in head and neck squamous cell carcinoma.

Zhichao Zhang1, Xusheng Ren2, Yiling Wang2

  • 1Department of Oral and Maxillofacial Surgery, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong, China.

BMC Oral Health
|June 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

High expression of Collagen triple helix repeat containing 1 (CTHRC1) in head and neck squamous cell carcinoma (HNSCC) indicates a poor prognosis and links to immune cell infiltration. CTHRC1 may serve as a valuable tumor marker for HNSCC.

Keywords:
BioinformaticsBiomarkerCTHRC1HNSCC

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with high mortality.
  • Collagen triple helix repeat containing 1 (CTHRC1) is overexpressed in various cancers, but its role in HNSCC is not fully understood.

Purpose of the Study:

  • To investigate CTHRC1 expression patterns in HNSCC.
  • To analyze the prognostic implications of CTHRC1 in HNSCC.
  • To explore the relationship between CTHRC1 and the tumor immune microenvironment in HNSCC.

Main Methods:

  • Bioinformatic analysis of TCGA and GEO datasets.
  • Kaplan-Meier analysis for prognostic assessment.
  • Gene Ontology, KEGG, and GSVA for enrichment analysis.
Immune infiltration
Tumor microenvironment
  • Analysis of CTHRC1 correlation with immune checkpoints and infiltration using CIBERSORT, TIMER, and ESTIMATE.

    • Main Results:

    • CTHRC1 is significantly overexpressed in HNSCC tumors compared to normal tissues.
    • Higher CTHRC1 expression correlates with advanced tumor stage and predicts a poor prognosis.
    • CTHRC1 expression is associated with extracellular matrix functions and immune cell infiltration, particularly activated macrophages.

    Conclusions:

    • Elevated CTHRC1 expression is a predictor of poor prognosis in HNSCC.
    • CTHRC1 is linked to immune infiltration in the HNSCC tumor microenvironment.
    • CTHRC1 demonstrates potential as a diagnostic and prognostic biomarker for HNSCC.