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During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
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Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
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Basket Trials: Past, Present, and Future.

Yonina R Murciano-Goroff1, Manik Uppal1,2, Monica Chen1

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Annual Review of Cancer Biology
|June 28, 2024
PubMed
Summary
This summary is machine-generated.

Disease-agnostic basket trials test targeted therapies across cancer types, accelerating drug approvals and understanding of cancer biology. Implementing these trials requires careful biomarker selection and equitable patient access for effective molecularly targeted drug development.

Keywords:
basket trialsbiomarker-selected trialsdisease-agnostic drug developmentgenomic biomarkersmolecular oncologyprecision oncology

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Area of Science:

  • Oncology
  • Translational Medicine
  • Clinical Trial Design

Background:

  • Tumor molecular profiling reveals common cancer pathways and biomarkers exploitable for therapy.
  • Disease-agnostic basket trials are increasingly used to test biomarker-driven therapies across diverse histologies.
  • These trials have led to drug approvals and advanced cancer biology understanding.

Purpose of the Study:

  • To review the practical implementation of molecularly targeted basket trials.
  • To examine biomarker and patient selection, study design, and recruitment strategies.
  • To highlight methods for improving patient access to basket trials.

Main Methods:

  • Review of existing literature on basket trial design and implementation.
  • Analysis of successes and challenges in molecularly targeted drug development via basket trials.
  • Discussion of novel targets, drugs, and practical considerations for trial execution.

Main Results:

  • Basket trials facilitate drug development by targeting common molecular pathways across histologies.
  • Successful implementation hinges on precise genomic biomarker and patient selection.
  • Strategies for participant recruitment and equitable access are crucial for trial success.

Conclusions:

  • Basket trials are effective for developing biomarker-driven therapies across cancer types.
  • Careful planning regarding molecular targets, patient selection, and study logistics is essential.
  • Ensuring equitable access to basket trials is critical for advancing molecularly targeted drug development.