Related Experiment Video

Updated: Jul 18, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.3K

Outcomes of Transcatheter Aortic Valve Replacement in Patients With Coexisiting Amyloidosis: Mortality, Stroke, and

Mohammed Elzeneini1, Shishir Gupta2, Yazan Assaf3

  • 1Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.

JACC. Advances
|June 28, 2024
PubMed

Insights

Cardiac amyloidosis patients undergoing transcatheter aortic valve replacement (TAVR) have a higher risk of stroke. However, amyloidosis did not significantly impact in-hospital mortality or 30-day readmission rates following TAVR.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Imaging

Background:

  • Cardiac amyloidosis frequently coexists with severe aortic stenosis.
  • Limited data exists on the impact of cardiac amyloidosis on outcomes after transcatheter aortic valve replacement (TAVR).

Purpose of the Study:

  • To investigate the effect of cardiac amyloidosis on in-hospital mortality, acute ischemic stroke, and 30-day readmission rates following TAVR.

Main Methods:

  • Utilized the Nationwide Readmissions Database (2016-2019) to identify TAVR hospitalizations.
  • Identified patients with and without a diagnosis of cardiac amyloidosis.
  • Employed propensity score-weighted regression analysis to assess outcomes.

Main Results:

  • Out of 245,020 TAVR hospitalizations, 273 involved patients with cardiac amyloidosis.
  • No significant differences were observed in in-hospital mortality or 30-day readmission rates between groups.
  • Patients with cardiac amyloidosis exhibited a significantly higher rate of acute ischemic stroke (6.2% vs 1.8%, P < 0.001).
  • Logistic regression confirmed amyloidosis was associated with increased odds of acute ischemic stroke (OR: 3.08, P=0.005).

Conclusions:

  • Cardiac amyloidosis may be associated with an elevated risk of thromboembolic events post-TAVR.
  • Further research is warranted to explore this increased stroke risk in patients with cardiac amyloidosis undergoing TAVR.
Abstract

Keywords:
amyloidosisstroketranscatheter aortic valve replacement

More Related Videos

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.1K
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.4K

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...