Injectable and Near-Infrared Light-Controllable Fibrin Hydrogels with Antimicrobial and Immunomodulating Properties...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Antibiotic resistance necessitates alternative strategies for infected wound management.
• Developing therapies that eliminate bacteria without inducing multi-drug resistance is crucial.

Purpose of the Study:

• To develop an injectable fibrin gel loaded with nanoparticles for infected wound healing.
• To create a therapeutic system combining antibacterial and immunomodulatory properties.

Main Methods:

• Fabrication of SNO-loaded MPDA nanoparticles (SMPDA) via electrostatic interaction.
• Encapsulation of SMPDA into fibrin gel (FG) to form SMPDA/G using a double-barreled syringe.

Main Results:

• SMPDA/G demonstrated effective elimination of bacterial infections in wounds.
• The formulation altered the immune microenvironment by promoting M2 macrophage polarization.
• Synergistic effects of nitric oxide and photothermal therapy contributed to efficacy.

Conclusions:

• The developed SMPDA/G is a promising therapeutic for infected wound healing.
• This approach offers an alternative to conventional antibiotic treatments.
• The combination therapy shows potential for clinical translation.