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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Jun 22, 2025

Basophil Activation Test for Allergy Diagnosis
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Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

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Food allergies around the world.

Gary Wing-Kin Wong1

  • 1Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Frontiers in Nutrition
|June 28, 2024
PubMed
Summary

Food allergy prevalence is rising globally, particularly in urban areas, affecting many children. Understanding urban-rural disparities is key to developing effective food allergy prevention strategies.

Area of Science:

  • Allergy and immunology
  • Epidemiology
  • Public health

Background:

  • Food allergy is a growing global health concern, representing the second wave of the allergy epidemic.
  • Allergic conditions, including food allergy, are increasingly linked to economic development and urbanization.
  • In developed nations, up to one-third of children experience allergic disorders, with food allergy often being the initial manifestation.

Purpose of the Study:

  • To explore the epidemiological trends of food allergy.
  • To investigate the disparity in food allergy prevalence between urban and rural populations.
  • To identify potential pathways for primary prevention of food allergy.

Main Methods:

  • This study reviews existing epidemiological data on food allergy prevalence.
Keywords:
anaphylaxisepidemiologyfood allergyglobalrisk factor

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  • It analyzes the correlation between urbanization and allergic conditions.
  • It examines variations in common food allergens across different regions.
  • Main Results:

    • Food allergy prevalence is significantly higher in urbanized areas compared to rural settings.
    • Common allergens vary between developed and developing countries.
    • Childhood anaphylaxis is frequently triggered by food allergens.

    Conclusions:

    • Urbanization and economic development are associated with increased food allergy rates.
    • Understanding the urban-rural divide in food allergy is crucial for targeted prevention.
    • Further research into the etiology of food allergy disparities is warranted.