Comparison of 2 Fillers for Lip Injection-A Randomized-Controlled Clinical Trial Assessed by 3D Imaging

Area of Science:

• Aesthetic Medicine
• Dermatology
• Biomaterials Science

Background:

• Lip aging is a common aesthetic concern.
• Hyaluronic acid (HA) injections are a popular lip augmentation solution.

Purpose of the Study:

• To compare the efficacy of two distinct hyaluronic acid (HA) gel technologies: OBT (Optimal Balance Technology) and NASHA (Non-Animal Stabilized Hyaluronic Acid).
• To evaluate lip volume changes and patient satisfaction following lip augmentation with OBT and NASHA gels.

Main Methods:

• Twenty volunteers received lip augmentation from the same injector using identical techniques.
• Lip volume was quantified using 3D stereophotogrammetry at baseline, immediately post-treatment, and 30 days post-treatment.
• Patient-reported outcomes, including satisfaction and adverse events, were assessed using FACE-Q scales.

Main Results:

• The NASHA group demonstrated an immediate significant increase in lip volume (P=.01), which diminished by 30 days.
• The OBT group showed no significant immediate volume change (P=.535) but achieved a significant increase at 30 days (P=.014).
• No significant differences in lip volume or patient satisfaction were observed between the OBT and NASHA groups at 30 days.

Conclusions:

• Less cohesive HA gels may alter more rapidly in dynamic lip areas, underscoring the importance of selecting products based on physicochemical properties.
• Immediate aesthetic outcomes in HA lip augmentation may not be definitive, as volume changes can evolve over time.