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Morphogenesis in Candida albicans.

F C Odds

    Critical Reviews in Microbiology
    |January 1, 1985
    PubMed
    Summary

    Environmental factors control Candida albicans morphology. This review surveys cellular events, cell wall synthesis, and models of dimorphic change in this important fungal pathogen.

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    Area of Science:

    • Microbiology
    • Mycology
    • Cell Biology

    Background:

    • Candida albicans is an opportunistic fungal pathogen that exhibits dimorphism, switching between yeast and hyphal forms.
    • Morphological transitions are crucial for C. albicans virulence and pathogenesis.
    • Environmental cues significantly influence the morphological state of C. albicans.

    Purpose of the Study:

    • To review environmental factors affecting Candida albicans morphology.
    • To describe cellular and ultrastructural changes during C. albicans morphological transitions.
    • To connect biochemical aspects of dimorphism to C. albicans cell biology and critically evaluate models of fungal dimorphism.

    Main Methods:

    • Literature review of environmental controls on C. albicans morphology.
    • Analysis of cellular and ultrastructural events in morphological transitions.
    • Examination of biochemical phenomena associated with dimorphism.
    • Critical review of proposed models for C. albicans dimorphism.

    Main Results:

    • Environmental conditions are key regulators of C. albicans morphology.
    • Cell wall synthesis and its regulation are critical for shape determination but remain poorly understood.
    • Specific cellular and ultrastructural events underpin the yeast-to-hyphal transition.
    • Biochemical pathways linked to dimorphism require further elucidation in the context of cell biology.

    Conclusions:

    • The cell wall is a principal determinant of C. albicans shape.
    • Understanding the environmental control of C. albicans dimorphism is vital for developing therapeutic strategies.
    • Further research into cell wall synthesis and biochemical regulation is needed to fully understand C. albicans morphogenesis.

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