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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Navigating Viral Gastroenteritis: Epidemiological Trends, Pathogen Analysis, and Histopathological Findings.

Poonam C Sharma1, Martin McCandless2, Sumit P Sontakke3

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Viral gastroenteritis significantly impacts pediatric patients, with norovirus being a common cause. Early diagnosis and surveillance are crucial, especially during outbreaks in communities.

Keywords:
adenovirusastrovirusnorovirusrotavirussapovirusviral gastroenteritis

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Area of Science:

  • Gastroenterology
  • Virology
  • Epidemiology

Background:

  • Gastroenteritis is a global health concern with diverse etiologies, including viral agents.
  • Viral gastroenteritis presents with symptoms like nausea, vomiting, and diarrhea, and frequently occurs in community outbreaks.
  • Accurate diagnosis and management strategies are essential for healthcare providers.

Purpose of the Study:

  • To analyze the prevalence and characteristics of viral gastroenteritis in a healthcare setting.
  • To identify common viral pathogens responsible for gastroenteritis across different age groups.
  • To understand the clinical and histopathological findings associated with viral gastroenteritis.

Main Methods:

  • Retrospective analysis of de-identified patient data over five years from an electronic health record.
  • Utilized BioFire® FilmArray® multiplex polymerase chain reaction for viral pathogen detection.
  • Included adenovirus, astrovirus, norovirus, rotavirus, and sapovirus in the analysis; reviewed histopathology when available.

Main Results:

  • Viral pathogens accounted for 25.46% of gastroenteritis cases.
  • Pediatric patients (72.73%) were significantly more affected than adults (27.07%).
  • Norovirus (genogroups I and II) was the most prevalent virus, particularly in adults. Histopathology showed inflammation and viral inclusion bodies.

Conclusions:

  • Viral gastroenteritis represents a significant health burden, with a notable impact on pediatric populations.
  • Norovirus is a key viral agent, underscoring the need for ongoing surveillance and prompt diagnosis.
  • Effective management strategies are vital, especially in outbreak-prone settings.