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GOSERELIN INHIBITING UPTAKE ON SODIUM PERTECHNETATE Tc-99M THYROID SCAN: A CASE REPORT

Y A Onimode1,2, O O Oyeyiola1

  • 1Department of Nuclear Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.

Annals of Ibadan Postgraduate Medicine
|June 28, 2024
PubMed
Abstract

Insights

Goserelin, a medication for endometriosis, can induce thyroiditis and affect thyroid function. This may lead to reduced uptake on sodium pertechnetate Tc-99m thyroid scans, impacting diagnostic accuracy.

Area of Science:

  • Endocrinology
  • Oncology
  • Gynecology

Background:

  • Goserelin, a gonadotropin-releasing hormone analogue, is used for endometriosis treatment.
  • Goserelin therapy can potentially induce thyroiditis, affecting thyroid function.
  • Altered thyroid function may interfere with diagnostic imaging, such as sodium pertechnetate Tc-99m scans.

Purpose of the Study:

  • To report a rare case of goserelin-induced thyroiditis.
  • To highlight the impact of goserelin on thyroid function and thyroid scan uptake.
  • To increase awareness among healthcare providers regarding goserelin's potential effects on thyroid function.

Main Methods:

  • Case report of a middle-aged woman with symptomatic toxic goiter.
  • Review of patient's medical history and treatment with goserelin.
  • Analysis of sodium pertechnetate Tc-99m thyroid scan results during goserelin therapy.

Main Results:

  • The patient presented with symptomatic toxic goiter.
  • Goserelin therapy was associated with inhibited uptake on the sodium pertechnetate Tc-99m thyroid scan.
  • This suggests goserelin-induced thyroiditis can affect thyroid imaging.

Conclusions:

  • Goserelin can induce thyroiditis, potentially altering thyroid function.
  • Healthcare providers must be aware of goserelin's impact on thyroid function and diagnostic scans.
  • Monitoring thyroid function in patients receiving goserelin is crucial.
Keywords:
Case reportEndometriosisGnRH agonistGoserelinSodium pertechnetate Tc99mThyroid gland

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