HYPERTENSION AND DIABETES MELLITUS ARE ASSOCIATED WITH DEEP VENOUS THROMBOEMBOLISM: A CASE CONTROL STUDY

Area of Science:

• Medical Research
• Hematology
• Clinical Medicine

Background:

• Identifying venous thromboembolism (VTE) risk factors is crucial for effective thromboprophylaxis.
• Previous studies suggested hypertension and diabetes mellitus as potential VTE risk factors in this population.

Purpose of the Study:

• To confirm the association of hypertension and diabetes mellitus with VTE.
• To evaluate the utility of complete blood count and coagulation tests in VTE risk stratification for prophylaxis.

Main Methods:

• A prospective, gender and age-matched case-control study.
• Involved 45 patients with Doppler-confirmed deep vein thrombosis (DVT) and 43 healthy controls.
• Analyzed medical history, complete blood count, and coagulation parameters (INR, aPTT).

Main Results:

• Hypertension, diabetes mellitus, and previous DVT were significant risk factors.
• Cases showed lower mean hematocrit, and significant differences in leucocytosis/leucopaenia and thrombocytosis/thrombocytopaenia.
• Elevated INR and prolonged aPTT were observed in cases, indicating altered coagulation states.

Conclusions:

• Hypertension and diabetes mellitus are confirmed risk factors for DVT, extending beyond traditional associations.
• Complete blood count and coagulation tests provide valuable parameters for stratifying VTE risk and guiding prophylaxis decisions.
• Findings are applicable to the studied population and similar communities.