[Effect of metabolic reprogramming on abdominal aortic aneurysm]

Area of Science:

• Biochemistry
• Cardiovascular Biology
• Cellular Metabolism

Background:

• Abdominal aortic aneurysm (AAA) is a dangerous condition often detected late, lacking effective pharmaceutical treatments.
• Metabolic reprogramming, altering cellular energy and material pathways, is increasingly linked to cardiovascular diseases.

Purpose of the Study:

• To review the role of metabolic reprogramming in vascular smooth muscle cells (VSMCs) and macrophages in AAA pathogenesis.
• To highlight metabolic targets for AAA prevention and treatment.

Main Methods:

• Literature review focusing on cellular metabolism in AAA.
• Analysis of VSMC and macrophage metabolic alterations in AAA pathology.

Main Results:

• Metabolic reprogramming influences key AAA processes: VSMC apoptosis and phenotype changes, extracellular matrix remodeling, oxidative stress, and inflammation.
• Specific metabolic pathways in VSMCs and macrophages are critical to AAA progression.

Conclusions:

• Metabolic reprogramming is a significant factor in AAA development.
• Targeting cellular metabolism presents a promising avenue for novel AAA therapies.