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Exploring the Neuroinflammatory Pathway in Epilepsy and Cognitive Impairment: Role of HMGB1 and Translational

Irma Wati Ngadimon1, Eryse Amira Seth1, Mohd Farooq Shaikh1,2

  • 1Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, SGR 47500, Malaysia.

Frontiers in Bioscience (Landmark Edition)
|June 28, 2024
PubMed

Keywords:
HMGB1cognitive comorbidityepilepsyneuroinflammatory biomarker

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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