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Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives
Waqas Ahmed1,2, Asim Mushtaq3, Shahzad Ali1,2
1Department of Orthopedics, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong, China.
ACS Biomaterials Science & Engineering
|June 28, 2024
Summary
Engineered exosomes offer promising drug delivery vehicles due to their biocompatibility. This review explores exosome modification strategies and their potential in targeted therapies for pharmaceutical development.
Area of Science:
- Biotechnology
- Nanomedicine
- Drug Delivery Systems
Background:
- Exosomes are nanoscale vesicles secreted by cells, possessing inherent biocompatibility and low immunogenicity.
- Native exosomes carry diverse biomolecules, making them natural candidates for therapeutic applications.
- Engineered exosomes can be modified to enhance their drug-carrying capacity and targeting efficiency.
Purpose of the Study:
- To review exosome modification strategies and drug loading techniques for engineered exosomes.
- To provide an overview of advancements in using engineered exosomes for targeted drug delivery.
- To discuss the advantages and disadvantages of chemically versus bioengineered exosome-mediated therapies.
Main Methods:
- Literature review of exosome engineering and drug delivery applications.
- Analysis of chemical and bioengineering methodologies for exosome modification.
- Evaluation of current research on targeted delivery using engineered exosomes.
Main Results:
- Various chemical and bioengineering methods enable exosome modification for specific therapeutic payloads.
- Engineered exosomes demonstrate potential for precise drug delivery to target cells and tissues.
- Both chemical and bioengineering approaches have distinct merits and limitations in exosome-mediated therapies.
Conclusions:
- Engineered exosomes represent a versatile platform for advancing targeted drug delivery.
- Further refinement of exosome engineering holds promise for pharmaceutical development.
- Successful translation of engineered exosomes from research to clinical application is anticipated.
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