The association between frailty biomarkers and 20-year all-cause and cardiovascular mortality among community-dwelling older adults
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View abstract on PubMed
Summary
This summary is machine-generated.Low alanine aminotransferase (ALT) and high homocysteine levels are linked to frailty and mortality in older adults. These accessible biomarkers can aid in screening for frailty and predicting mortality risk, particularly in those with ischemic heart disease.
Area Of Science
- Gerontology
- Biomarkers
- Public Health
Background
- Frailty and mortality in older adults are significant public health concerns.
- Existing biomarkers for frailty and mortality have shown inconsistent results.
- Understanding the pathophysiology of frailty requires novel biomarker evaluation.
Purpose Of The Study
- To investigate the association between novel biomarkers and frailty in community-dwelling older adults.
- To determine the relationship between these biomarkers and all-cause and cardiovascular mortality.
- To identify potential screening biomarkers for frailty and mortality risk.
Main Methods
- A cohort of 963 older adults from the Israel study on Glucose Intolerance, Obesity, and Hypertension (GOH) was analyzed.
- Frailty was defined using criteria including BMI, albumin levels, disease burden, and lifestyle factors.
- Biomarkers, including alanine aminotransferase (ALT) and homocysteine, were assessed for their association with frailty and mortality outcomes.
Main Results
- Lower alanine aminotransferase (ALT) levels were associated with increased odds of frailty.
- Elevated homocysteine levels were significantly linked to higher frailty risk.
- Both low ALT and high homocysteine were associated with increased all-cause and cardiovascular mortality risk.
- The association between homocysteine and mortality was more pronounced in individuals with pre-existing ischemic heart disease (IHD).
Conclusions
- Reduced ALT and elevated homocysteine are significant predictors of frailty and mortality in older adults.
- These biomarkers offer a low-cost and accessible method for screening high-risk populations.
- The findings highlight the importance of nutritional and metabolic factors in the pathophysiology of frailty and mortality.
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