Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.3K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.3K
Pulmonary Function Tests01:25

Pulmonary Function Tests

317
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
317
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patients' perspectives of eosinophilic granulomatosis with polyangiitis within the context of a clinical trial.

EULAR rheumatology open·2026
Same author

Patient perspectives on glucocorticoid-associated complications and sequelae in ANCA-associated vasculitis.

EULAR rheumatology open·2026
Same author

EGPAware: a European Delphi consensus study on red flags for suspicion of eosinophilic granulomatosis with polyangiitis.

EULAR rheumatology open·2026
Same author

Treatment strategies in giant cell arteritis and polymyalgia rheumatica: beyond glucocorticoids.

Nature reviews. Rheumatology·2026
Same author

[Update on Treatment of Large Vessel Vasculitides].

Deutsche medizinische Wochenschrift (1946)·2026
Same author

TEG 6s thrombelastography versus conventional coagulation assays in infants and toddlers during craniosynostosis surgery: a prospective observational clinical study.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

Related Experiment Video

Updated: Jun 22, 2025

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
07:09

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

13.1K

Pulmonary function in patients with ANCA-associated vasculitis.

Johannes Dieterich1, Bernhard Hellmich1, Juliane Mahrhold1

  • 1medius Klinik Kirchheim, Department of Internal Medicine, Rheumatology, Pulmonology, Nephrology and Diabetology.

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
|June 28, 2024
PubMed
Summary

ANCA-associated vasculitis (AAV) patients show specific pulmonary function test alterations linked to their lung conditions. These changes persist over time and are unrelated to disease activity.

More Related Videos

Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

15.6K
Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

27.7K

Related Experiment Videos

Last Updated: Jun 22, 2025

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
07:09

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

13.1K
Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

15.6K
Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

27.7K

Area of Science:

  • Pulmonology
  • Rheumatology
  • Immunology

Background:

  • Pulmonary manifestations are common in ANCA-associated vasculitis (AAV).
  • Empirical data on the impact of AAV on pulmonary function is limited.
  • This study investigates pulmonary function test (PFT) results in a large AAV cohort.

Purpose of the Study:

  • To analyze PFT data in AAV patients.
  • To correlate PFT findings with imaging and disease activity.
  • To identify specific PFT alterations in different AAV subtypes.

Main Methods:

  • Retrospective analysis of PFT data from 147 AAV patients (2008-2018).
  • Comparison of PFT results with demographic, disease, and imaging characteristics.
  • Assessment of changes over time and correlation with disease activity.

Main Results:

  • Granulomatosis with Polyangiitis (GPA) showed reduced FVCex, RV, and TLCO.
  • Microscopic Polyangiitis (MPA) exhibited reduced FVCex, TLC, and TLCO.
  • Eosinophilic Granulomatosis with Polyangiitis (EGPA) had increased RAWtot, elevated RV, and reduced TLCO.
  • Interstitial lung disease (ILD) was associated with significant declines in FVCex, TLC, RV, and TLCO.
  • No significant differences were found between initial and follow-up PFTs or between active and inactive disease states.

Conclusions:

  • AAV patients exhibit distinct PFT alterations based on pulmonary and airway involvement.
  • These PFT changes are stable over time.
  • PFT findings in AAV are independent of current disease activity.