Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sensory Functions of the Skin

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dermatologie (Heidelberg, Germany)·2024

Same author

[Systemic pruritus: what is new in diagnosis and treatment?]

Dermatologie (Heidelberg, Germany)·2022

Same author

The amount of liver tissue is essential for accurate histological staging in patients with autoimmune hepatitis.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2021

Same author

Beyond the border: the use of lenvatinib in advanced hepatocellular carcinoma after different treatment lines: a retrospective analysis.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2021

Same author

[Brain teasers in pruritus-when laboratory tests will guide you].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2020

Same author

[Pruritus in systemic diseases : Common and rare etiologies].

Der Internist·2019

Search research articles

Related Experiment Video

Updated: Jun 22, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

[Recommended diagnostics for pruritus affecting primary non-lesional skin].

M M Düll¹, A E Kremer^2,3

¹Medizinische Klinik 1, Gastroenterologie, Pneumologie, Endokrinologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.

Dermatologie (Heidelberg, Germany)

|June 28, 2024

Summary

Chronic pruritus affecting primary non-lesional skin (CPNL) is challenging to diagnose. A stepwise approach using clinical, lab, and imaging diagnostics helps identify underlying causes for effective treatment.

Keywords:

Basic diagnostic workup Itch Liver Myeloproliferative neoplasms Stepwise diagnostic strategy

More Related Videos

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Related Experiment Videos

Last Updated: Jun 22, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Area of Science:

Dermatology and Internal Medicine
Diagnostic Challenges in Pruritus
Multidisciplinary Approach to Itch

Context:

Chronic pruritus affecting primary non-lesional skin (CPNL) is a common yet diagnostically complex symptom.
Diverse underlying etiologies span multiple medical specialties.
Identifying the root cause of CPNL is crucial for patient management.

Purpose:

To offer a comprehensive overview of diagnostic strategies for CPNL.
To detail clinical, laboratory, and imaging diagnostic methods.
To guide clinicians in evaluating patients with non-lesional chronic itch.

Summary:

A systematic, stepwise diagnostic approach is recommended for CPNL.
Initial basic diagnostics provide a cost-effective foundation.
Specialized procedures refine the identification of underlying diseases.

Impact:

Facilitates accurate diagnosis of pruritus-associated conditions.
Enables targeted and effective pruritus-specific pharmacotherapy.
Improves patient outcomes by addressing the root cause of chronic itch.