Biofabrication strategies for cardiac tissue engineering

Area of Science:

• Biomedical Engineering
• Tissue Engineering
• Cardiovascular Research

Background:

• Current biofabrication technologies offer potential for creating complex cardiac models.
• Key parameters for advanced cardiac models include size, printing resolution, biocompatibility, and ease of fabrication.

Purpose of the Study:

• To review recent advancements in cardiac engineering technologies.
• To discuss the translation of these models for in vivo and in vitro applications.

Main Methods:

• Review of microscaled organoids, heart-on-a-chip platforms, and in vitro ventricle models.
• Examination of larger cardiac patches and associated biofabrication techniques.
• Discussion of advancements facilitating model translation.

Main Results:

• Biofabrication enables high-throughput, cost-effective cardiac models.
• Various scales of cardiac models are being developed, from organoids to larger patches.
• Models show promise for drug testing and disease modeling.

Conclusions:

• Continued advancements in biofabrication are crucial for developing sophisticated cardiac models.
• These engineered cardiac models have significant potential for both in vitro research and in vivo therapeutic applications.