Related Experiment Video
Updated: Jun 22, 2025
07:38
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
493
Isoniazid-induced pancreatitis: A systematic review
Tejaswini Baral1, Sonal Sekhar M1, Levin Thomas1
1Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Tuberculosis (Edinburgh, Scotland)
|June 28, 2024
Summary
Isoniazid-induced pancreatitis is a serious adverse drug reaction. Early diagnosis and drug discontinuation are crucial for patient recovery, as evidenced by 16 reviewed case reports.
Area of Science:
- Pharmacovigilance
- Hepatology
- Gastroenterology
Background:
- Isoniazid is a first-line antituberculosis drug.
- Isoniazid-induced pancreatitis is a rare but serious adverse drug reaction.
- The exact frequency of isoniazid-induced pancreatitis remains unknown.
Purpose of the Study:
- To systematically review and comprehensively explore isoniazid-induced pancreatitis.
- To determine the characteristics and outcomes of patients experiencing this adverse drug reaction.
Main Methods:
- Systematic literature search of major databases (PubMed, Web of Science, Scopus, Ovid, Embase).
- Inclusion of case reports detailing isoniazid-induced pancreatitis.
- Descriptive analysis and risk of bias assessment of eligible cases.
Main Results:
- Sixteen case reports from eight countries involving 16 patients were included.
- Most cases occurred in patients with extrapulmonary tuberculosis.
- Mean patient age was 36.7 years, and all cases resolved upon isoniazid discontinuation.
Conclusions:
- The latency period for isoniazid-induced pancreatitis ranged from 12 to 45 days.
- Early screening for pancreatitis (e.g., pancreatic enzymes) in patients with abdominal pain on isoniazid is recommended.
- Prompt diagnosis and isoniazid discontinuation can reduce pancreatitis severity and prevent complications.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
118
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
118
01:27Acute Pancreatitis I: Introduction
353
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
353
01:24Chronic Pancreatitis I: Introduction
86
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
86
01:29Chronic Pancreatitis II: Collaborative Care
84
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
84
01:23Dipeptidyl Peptidase 4 Inhibitors
180
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
180