Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Robustness of LET<sub>d</sub>-optimized multi-ion therapy against range and setup uncertainties: evaluation and enhancement with carbon-, oxygen-, and neon-ion beams.

Physics in medicine and biology·2026

Same author

Neon ion radiotherapy: physics and biology.

Physics in medicine and biology·2025

Same author

Evaluation of diamond and silicon detectors for linear energy transfer measurements of therapeutic helium, carbon, oxygen, and neon ion beams.

Physics in medicine and biology·2025

Same author

In-beam range determination using an OpenPET system for helium, carbon, oxygen, and neon ion beams.

Physics in medicine and biology·2025

Same author

Design of multi-ion therapy for head and neck cancers using carbon-, oxygen-, and neon-ion beams: potential efficacy against tumor hypoxia.

Physics in medicine and biology·2025

Same author

Effects of intra-tumoral cellular heterogeneity of oxygen partial pressure on biological effectiveness of hydrogen-, helium-, carbon-, oxygen-, and neon-ion beams.

Physics in medicine and biology·2025

Search research articles

Related Experiment Video

Updated: Jun 22, 2025

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

Method for fabricating a mesh ripple filter for charged-particle therapy.

Sodai Tanaka¹, Taku Inaniwa¹

¹Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.

Physics in Medicine and Biology

|June 28, 2024

Summary

Researchers developed a method to fabricate multi-mesh ripple filters (mRiFi) for heavy-ion therapy. This method optimizes filter parameters to widen the Bragg peak while controlling beam spread, enabling precise radiation delivery.

Keywords:

charged-particle therapy mesh ripple filter multi-ion therapy

More Related Videos

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Published on: March 6, 2016

Related Experiment Videos

Last Updated: Jun 22, 2025

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Fabrication and Operation of Acoustofluidic Devices Supporting Bulk Acoustic Standing Waves for Sheathless Focusing of Particles

Published on: March 6, 2016

Area of Science:

Medical Physics
Radiation Therapy
Accelerator Physics

Background:

Heavy-ion therapy requires precise dose delivery, often necessitating Bragg peak modification.
Multi-mesh ripple filters (mRiFi) are low-cost devices for widening the Bragg peak.
Optimal mRiFi fabrication parameters for Bragg peak shifting and widening were previously undetermined.

Purpose of the Study:

To clarify how mRiFi parameters influence Bragg peak characteristics and beam lateral spread.
To develop a fabrication recipe for mRiFi with desired performance.
To validate the proposed method through experiments with various ion beams.

Main Methods:

Established an analytical calculation method to predict Bragg peak shift, widening, and lateral spread.
Validated the analytical method using Monte Carlo simulations.
Fabricated mRiFi using the developed recipe and evaluated performance with helium, carbon, oxygen, and neon beams.

Main Results:

Analytical calculations showed high agreement with Monte Carlo simulations (peak shift < 0.4 mm, peak width < 0.15 mm, lateral size < 0.11 mm).
Experimental results for Bragg peak shift and width validated the analytical predictions.
The developed mRiFi demonstrated effective Bragg peak widening with acceptable beam characteristics.

Conclusions:

A reliable method for determining mRiFi parameters to achieve desired Bragg peak widening and controlled beam spread was proposed.
This method enables the fabrication of simple, low-cost mRiFi for multi-ion therapy.
The findings facilitate reproducible and precise heavy-ion radiation delivery.