Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
Types of Toxins01:36

Types of Toxins

1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Relative Risk01:12

Relative Risk

149
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
149

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Designing recruitment strategies for population-based human biomonitoring: evidence on participation and representativeness from Latvia.

Archives of public health = Archives belges de sante publique·2026
Same author

Dietary patterns and pesticide exposure in rural Latvia: evidence from a human biomonitoring study.

Scientific reports·2026
Same author

Corrigendum to "Environmental exposure and cancer incidence in offshore petroleum workers in Norway" [Environ. Res. 264 (2025) 121407].

Environmental research·2026
Same author

Phospholipid composition in small airway lining fluid among tunnel construction workers exposed to respirable crystalline silica.

Lipids in health and disease·2025
Same author

Exposures in Indoor Air Affecting Health.

Allergy·2025
Same author

Occupational exposure to graphene-related materials: from workplace emissions to health risk assessment.

Nanoscale·2025

Related Experiment Video

Updated: Jun 22, 2025

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
00:05

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

13.9K

Occupational exposure limits for reproductive toxicants - A comparative analysis.

Linda Schenk1, Meng-Rung Ho1, Piia Taxell2

  • 1Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Reproductive Toxicology (Elmsford, N.Y.)
|June 28, 2024
PubMed
Summary

Occupational exposure limits (OELs) and derived no-effect levels (wDNELs) inadequately protect against reproductive toxicants. Many substances lack adequate exposure limits, and existing ones vary significantly, with some offering insufficient safety margins.

Keywords:
DNELHealth risk assessmentIndustrial hygieneMaximum allowable concentrationReproductive toxicologyRoute-to-route extrapolationTLVUncertainty factors

More Related Videos

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
08:00

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays

Published on: December 4, 2016

7.5K

Related Experiment Videos

Last Updated: Jun 22, 2025

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
00:05

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

13.9K
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
08:00

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays

Published on: December 4, 2016

7.5K

Area of Science:

  • Occupational Health and Safety
  • Toxicology
  • Chemical Risk Assessment

Background:

  • Occupational exposure limits (OELs) and derived no-effect levels for workers' inhalation exposure (wDNELs) are crucial for protecting workers from reproductive and developmental toxicity.
  • The effectiveness of these limits in covering known reproductive toxicants requires thorough investigation.

Purpose of the Study:

  • To assess the protection offered by OELs and wDNELs against reproductive and developmental toxicity.
  • To compare the coverage, numerical values, and scientific basis of various OEL and wDNEL lists for reproductive toxicants.

Main Methods:

  • Comparison of 14 lists of OELs and wDNELs against substances with harmonised classification as reproductive toxicant 1A or 1B.
  • Analysis of substance coverage, numerical values, scientific basis, and margin of safety for reproductive toxicity.

Main Results:

  • Only 53% of reproductive toxicants had at least one exposure limit across the examined lists.
  • REACH Registrants' wDNELs covered the largest share (40%), but numerical values varied widely.
  • 15% of safety margins were found to be insufficient for reproductive toxicity.

Conclusions:

  • Current OELs and wDNELs do not sufficiently cover known reproductive toxicants under REACH and work environment legislation.
  • European Union OELs cover fewer substances compared to other lists, and national OELs/wDNELs are often more conservative.