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Bioinductive patch as an augmentation for rotator cuff repair, a systematic review and meta-analysis
Jonathan R Warren1, El R Domingo-Johnson1, Amelia A Sorensen1
1Department of Orthopedic Surgery, University of Missouri Kansas City, Kansas City, MO, USA.
Journal of Shoulder and Elbow Surgery
|June 28, 2024
Summary
The bioinductive collagen patch shows promise in reducing rotator cuff repair retears and improving shoulder function. While complications are similar to traditional repairs, further case-control studies are needed to confirm its role.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Regenerative Medicine
Background:
- Rotator cuff tears (RCTs) are common, causing shoulder pain and dysfunction.
- Surgical repair (RCR) can fail due to retearing or nonhealing.
- Bioinductive collagen patches are a novel augmentation for RCR, but data are limited.
Purpose of the Study:
- To evaluate the efficacy and safety of bioinductive collagen patches in RCR.
- To compare outcomes of augmented RCR with historical data of traditional RCR.
- To perform a meta-analysis of complication and retear rates.
Main Methods:
- PRISMA-guided literature search of multiple databases.
- Inclusion of 13 clinical trials on full and partial-thickness RCTs.
- Meta-analysis of patient-reported outcomes, tendon thickness, and complication/retear rates.
Main Results:
- Significant improvements in shoulder scores and pain relief were observed.
- Tendon thickness increased similarly to traditional RCR.
- Retear rates were 8.3% (full-thickness) and 1.1% (partial-thickness); complication rates were 15.5% and 16.2%, respectively.
Conclusions:
- Bioinductive patches are safe augmentations for RCR, improving outcomes and potentially reducing retears.
- Further case-control studies are necessary to define the patch's role versus traditional RCR.
- The patch may mitigate retear risk, a long-standing concern in rotator cuff repair.
