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Updated: Jun 22, 2025

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Drug repurposing for bacterial infections.

Mahnoor Ilyas1, Muhammad Saad Latif2, Alvina Gul3

  • 1Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan; Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.

Progress in Molecular Biology and Translational Science
|June 28, 2024
PubMed
Summary

Drug repurposing finds new uses for existing medicines, saving time and resources. This approach is vital for developing new antibiotics to combat rising antimicrobial resistance.

Keywords:
AntibacterialAntihistaminesAntimicrobial resistance (AMR)BacteriaDrug repurposingInfectionsVirtual screening

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Area of Science:

  • Pharmaceutical Sciences
  • Infectious Diseases
  • Drug Discovery

Background:

  • Drug repurposing identifies novel applications for approved pharmaceuticals.
  • This strategy offers a faster, more cost-effective drug development pathway.
  • It is particularly valuable for addressing urgent health challenges like antimicrobial resistance.

Purpose of the Study:

  • To explore the drug discovery and development process for repurposing existing drugs.
  • To highlight the potential of drug repurposing in combating bacterial infections.
  • To discuss modifications in formulation, administration, and dosage for repurposing.

Main Methods:

  • Screening of approved drug libraries for targeted disease conditions.
  • In silico, in vitro, and in vivo experimentation to identify active molecules.
  • Evaluation of existing safety profiles to expedite clinical trials.

Main Results:

  • Drug repurposing significantly reduces development time and resource expenditure.
  • Existing drugs like Auranofin, Closantel, and Toremifene show promise for treating infections.
  • Adaptations in drug formulation, dosage, and administration routes enhance repurposing efficacy.

Conclusions:

  • Drug repurposing is an effective strategy against antimicrobial resistance.
  • It accelerates the availability of treatments for bacterial infections.
  • Further research into repurposing holds significant potential for public health.