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Drug repurposing for personalized medicine.

Jahnvi Hora1, Nishita Rambhia1, Indra Mani2

  • 1Manipal School of Life Science, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Progress in Molecular Biology and Translational Science
|June 28, 2024
PubMed
Summary

Personalized medicine tailors treatments using individual genetic and biological data, improving effectiveness and reducing side effects. Drug repurposing accelerates this by finding new uses for existing drugs, revolutionizing precision medicine.

Keywords:
Anxiety disordersBreast cancerCOVID-19Drug repurposingGlioblastomaHepatocellular carcinomaPersonalised medicinePrecision medicine

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Area of Science:

  • Biomedical Sciences
  • Pharmacology
  • Genomics

Background:

  • Personalized medicine offers tailored healthcare based on individual genetic and biological profiles.
  • It contrasts with traditional one-size-fits-all approaches, aiming for better efficacy and fewer adverse effects.
  • Drug repurposing leverages existing drugs' known safety and pharmacokinetic profiles for accelerated development.

Purpose of the Study:

  • To explore strategies where drug repurposing enhances precision medicine.
  • To highlight the application of these strategies in oncology and other diseases.
  • To demonstrate the potential for rapid development of novel treatment plans.

Main Methods:

  • Review of drug repurposing strategies applied to precision medicine.
  • Case studies in oncology (breast cancer, glioblastoma, hepatocellular carcinoma).
  • Examination of applications in anxiety disorders and COVID-19.

Main Results:

  • Drug repurposing shows significant success in advancing precision medicine.
  • Tailored treatments are particularly effective for genetically diverse cancers.
  • Existing drugs can be rapidly repurposed for new indications, including complex diseases.

Conclusions:

  • Drug repurposing is a powerful tool for accelerating personalized medicine.
  • This approach offers improved clinical outcomes and efficient healthcare resource utilization.
  • The integration of drug repurposing holds transformative potential for future therapies.