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Serum L C3-II levels in type 2 diabetic patients with impaired renal functions
Shahab Ahmed Salıh Gezh1, Koksal Deveci1, Hakan Sivgin2
1Tokat Gaziosmanpasa University, Faculty of Medicine, Department of Medical Biochemistry, 60100, Tokat, Turkey.
Abstract:
This study was designed to evaluate serum LC3-II, BCL-2, IL-1β, TGF-β1, and podocin levels in. type 2 diabetes (T2DM) patients with renal dysfunction.
Materials:
176 Turkish subjects were enrolled, of whom 26 were healthy, and 150 had T2DM.
Patients:
were classified according to albumin urea ratio: 88 patients had macroalbuminuria, 20. patients had microalbuminuria, and 42 had normoalbuminuria. T2DM patients were also. classified into three groups according to proteinuria and eGFR stages.
Results:
Increased serum LC3-II levels in patients with T2DM with increased urinary albumin. extraction and impaired renal functions. There was a strong relationship between serum. LC3-II levels and serum BCL-2, IL-1β, TGF-β1, and Podocin levels. The efficiency of LC3- II as a diagnostic biomarker in the differential diagnosis of DM patients with. macroproteinuria from DM patients with normoproteinuria was 75.4%.
Conclusions:
It was thought that increased serum LC3-II levels in T2DM patients with impaired renal. functions may cause renal podocyte damage. In these patients, serum LC3-II levels can be. evaluated as a new biomarker to follow the development of renal damage.
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