COVID-19 vaccine immunogenicity and safety surrounding fourth and subsequent vaccine doses in patients with hematologic malignancies
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View abstract on PubMed
Summary
This summary is machine-generated.Subsequent COVID-19 vaccine doses significantly improve antibody response in patients with hematologic malignancies. This study quantifies the humoral immune response to fourth and fifth doses, showing increased anti-Spike antibody levels.
Area Of Science
- Immunology
- Oncology
- Vaccinology
Background
- Patients with hematologic malignancies exhibit a diminished immune response to COVID-19 vaccines.
- Limited data exists on the vaccine response in this vulnerable patient population.
Purpose Of The Study
- To quantify the humoral immune response to 4th and subsequent SARS-CoV-2 vaccine doses in hematologic malignancy patients.
- To measure anti-Spike (anti-S) antibody levels using dried blood spot (DBS) testing as an indicator of vaccine immunogenicity.
Main Methods
- A prospective cohort study involving hematologic malignancy patients across 12 Canadian sites (August 2021-January 2023).
- Longitudinal follow-up with participants submitting finger-prick DBS cards post-vaccination.
- High-throughput ELISA assay used to detect anti-nucleocapsid (N) and anti-Spike (S) antibodies in processed DBS samples.
Main Results
- Analysis included 372 participants with 1840 samples post-4th, 5th, or 6th dose.
- Anti-Spike antibodies were detected in 77.2% post-4th dose and 90.6% post-5th dose.
- Subsequent doses demonstrated an improved humoral immune response, with a notable increase in positive anti-S antibody detection.
Conclusions
- Subsequent doses of COVID-19 vaccines lead to an improved humoral immune response in patients with hematologic malignancies.
- The study highlights the benefit of additional vaccine doses for enhancing immunogenicity in this immunocompromised group.
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