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Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma I: Introduction01:28

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Related Experiment Video

Updated: May 5, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Mediators, airway responsiveness, and asthma.

F E Hargreave, P M O'Byrne, E H Ramsdale

    The Journal of Allergy and Clinical Immunology
    |August 1, 1985
    PubMed
    Summary

    Asthma severity is closely linked to airway responsiveness and mediator release. Effective asthma treatment should target airway responsiveness, mediator release, and inflammation.

    Area of Science:

    • Pulmonology
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Airway responsiveness to stimuli is interconnected with asthma presence and severity.
    • Endogenous mediator release in airways plays a role in asthma pathology.
    • Histamine and methacholine are common agents for measuring airway responsiveness.

    Purpose of the Study:

    • To explore the interrelationships between airway responsiveness, asthma severity, and endogenous mediator release.
    • To understand the correlation between responsiveness to different stimuli, including natural ones like exercise and allergens.

    Main Methods:

    • Assessing airway responsiveness using pharmacologic agents like histamine and methacholine.
    • Correlating airway responsiveness measurements with asthma symptoms, airflow obstruction, and therapy.

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  • Comparing responsiveness to pharmacologic agents with responsiveness to natural stimuli.

    • Main Results:

    • Increased airway responsiveness to histamine and methacholine in symptomatic asthma patients.
    • Responsiveness to histamine closely correlates with methacholine responsiveness.
    • Responsiveness to natural stimuli like exercise and allergens shows weaker correlations, likely due to varied mediator release.

    Conclusions:

    • Airway hyperresponsiveness, mediator release, and airway inflammation are key components of asthma.
    • Asthma treatment strategies should aim to decrease airway responsiveness.
    • Therapeutic interventions should focus on preventing mediator release and reversing airway inflammation.