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Histamine-containing peripheral neuronal and endocrine systems.

P Panula, M Kaartinen, M Mäcklin

    The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
    |September 1, 1985
    PubMed
    Summary
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    This study developed a new method to detect histamine in tissues. Histamine was found in gut nerves, endocrine cells, and adrenal cells, suggesting broader roles beyond mast cells.

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Gastroenterology

    Background:

    • Histamine is traditionally known to be stored in mast cells.
    • Its presence and distribution in other tissues are less understood.

    Purpose of the Study:

    • To develop an immunohistochemical method for detecting histamine in tissues.
    • To investigate the cellular localization of histamine in the gastrointestinal tract, pituitary, and adrenal gland.

    Main Methods:

    • Development of a specific immunohistochemical staining technique.
    • Application of the method to analyze tissue samples from rats and guinea pigs.

    Main Results:

    • Histamine-containing nerve fibers were identified in the gastrointestinal tract of both rats and guinea pigs.

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  • Enterochromaffin-like cells in the rat stomach and endocrine cells in the rat ileum/jejunum showed histamine.
  • Histamine was localized to mast cells in the neurohypophysis and to process-bearing cells in the guinea pig adrenal medulla.

    • Conclusions:

    • Histamine is present in peripheral nerves and endocrine cells, expanding its known cellular distribution.
    • Histamine may function as a neurotransmitter or hormone in these newly identified locations.