Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

798
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
798
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

129
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
129
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

196
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
196
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

463
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
463
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

1.9K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.9K
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

256
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Oncolytic Viruses in Cancer Therapy: Mechanisms, Challenges, and Emerging Clinical Applications.

Annales pharmaceutiques francaises·2026
Same journal

Comparative Evaluation of Two Analytical Methods for Thymoquinone Determination and Their Correlation with Phenolic and Flavonoid Contents in Nigella sativa Biomass.

Annales pharmaceutiques francaises·2026
Same journal

[Off-label prescriptions of systemic antifungals in 2024 in the Auvergne-Rhône-Alpes region].

Annales pharmaceutiques francaises·2026
Same journal

[Artificial Intelligence in the Pharmaceutical Industry: Governance, Quality, and Regulatory Challenges].

Annales pharmaceutiques francaises·2026
Same journal

No evidence of significant natural environmental exposure to arsenic for Napoleon I on the island of Saint Helena (1815-1821).

Annales pharmaceutiques francaises·2026
Same journal

Effects of GLP-1 receptor agonists on periodontal tissue: An interdisciplinary evidence mapping - scoping review.

Annales pharmaceutiques francaises·2026

Related Experiment Video

Updated: Jun 22, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.1K

Nanosuspensions: Enhancing drug bioavailability through nanonization.

Rohit Chavhan1

  • 1Yash institute of pharmacy, Dharmapur, India.

Annales Pharmaceutiques Francaises
|June 30, 2024
PubMed
Summary

Nanosuspensions enhance bioavailability for poorly soluble drugs using nanonization. This pharmaceutical innovation offers versatile applications and improved drug delivery for better therapeutic outcomes.

Keywords:
Bioavailability enhancementDrug solubilityFormulation techniquesNanonizationNanosuspensionVersatile drug delivery

More Related Videos

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

22.0K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K

Related Experiment Videos

Last Updated: Jun 22, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.1K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

22.0K
Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

15.8K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Nanosuspensions are a key innovation for improving the bioavailability of poorly soluble drugs.
  • Nanonization techniques are crucial for reducing particle size and enhancing drug solubility.
  • Hydrophobic drugs pose challenges for conventional delivery methods, making nanosuspensions a valuable alternative.

Purpose of the Study:

  • To explore the transformative potential of nanosuspensions in pharmaceutical innovation.
  • To emphasize the critical role of particle size reduction in drug delivery.
  • To provide a comprehensive overview of nanosuspension technology.

Main Methods:

  • Investigated various preparation techniques: high-pressure homogenization, media milling, emulsification-solvent evaporation, precipitation, and supercritical fluid processes.
  • Highlighted the necessity for meticulous planning, evaluation, and ongoing research for optimal use.
  • Discussed formulation and stabilization strategies using polymers and surfactants.

Main Results:

  • Nanosuspensions demonstrate versatility across administration routes (parenteral, peroral, ocular, pulmonary).
  • They offer a promising solution for enhancing drug solubility and bioavailability.
  • Potential for site-specific medication administration and tailored therapeutic strategies.

Conclusions:

  • Nanosuspensions are a significant approach to overcoming bioavailability challenges.
  • Careful formulation and stabilization are essential for efficacy and safety.
  • Continued research and optimization are vital to fully harness the benefits of nanosuspensions in pharmaceutical sciences.