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Bone turnover markers reference database in five Southeast Asian countries.

Joon Kiong Lee1, Hui Min Khor2, Pojchong Chotiyarnwong3

  • 1Department of Orthopedic Surgery, Beacon Hospital, Petaling Jaya, Selangor, Malaysia.

Bone
|June 30, 2024
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Summary
This summary is machine-generated.

This study establishes the first reference ranges for bone turnover markers (BTMs) in Southeast Asian premenopausal women. These findings are crucial for accurate osteoporosis assessment and management in the region.

Keywords:
Bone turn over markerOsteoporosisSoutheast AsiaWomen

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Population Health

Background:

  • Osteoporosis prevalence is high, particularly in developing nations.
  • Established bone turnover marker (BTM) reference ranges are lacking for Asian populations.
  • Accurate BTMs are vital for osteoporosis diagnosis and monitoring.

Purpose of the Study:

  • To develop a regional BTM reference database for five ASEAN countries.
  • To establish reference intervals for serum Procollagen 1 N-Terminal Propeptide (P1NP), Osteocalcin (OC), and Beta-Crosslaps (CTX).
  • To provide a foundation for osteoporosis management in Southeast Asia.

Main Methods:

  • Combined country-specific data from Malaysia, Philippines, Singapore, Thailand, and Vietnam.
  • Analyzed 746 healthy premenopausal women aged 20-44 years.
  • Measured P1NP, OC, and CTX using automated immunoassay systems.

Main Results:

  • Established reference intervals: CTX (128-811 ng/L), OC (9.0-33.0 μg/L), P1NP (22.8-96.5 μg/L).
  • Excluding 20s: CTX (117-678 ng/L), P1NP (21.6-85.8 μg/L), OC (3.5-27.0 μg/L).
  • Observed inter-country variations and decreased BTMs with age after 30.

Conclusions:

  • This study presents the first BTM reference intervals for healthy premenopausal Southeast Asian women.
  • These intervals are essential for accurate bone turnover assessment in the region.
  • Contributes to improved osteoporosis evaluation and patient monitoring.