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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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  1. Home
  3. Research Domains
  5. Indigenous Studies
  7. Ngā Pūtaiao Māori (māori Sciences)
  9. Ngā Pūtaiao Koiora O Te Māori (māori Biological Sciences)
  11. Bone Turnover Markers Reference Database In Five Southeast Asian Countries.
  1. Home
  3. Research Domains
  5. Indigenous Studies
  7. Ngā Pūtaiao Māori (māori Sciences)
  9. Ngā Pūtaiao Koiora O Te Māori (māori Biological Sciences)
  11. Bone Turnover Markers Reference Database In Five Southeast Asian Countries.

Related Experiment Video

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Bone turnover markers reference database in five Southeast Asian countries.

Joon Kiong Lee1, Hui Min Khor2, Pojchong Chotiyarnwong3

  • 1Department of Orthopedic Surgery, Beacon Hospital, Petaling Jaya, Selangor, Malaysia.

Bone
|June 30, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study establishes the first reference ranges for bone turnover markers (BTMs) in Southeast Asian premenopausal women. These findings are crucial for accurate osteoporosis assessment and management in the region.

Keywords:
Bone turn over markerOsteoporosisSoutheast AsiaWomen

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Population Health

Background:

  • Osteoporosis prevalence is high, particularly in developing nations.
  • Established bone turnover marker (BTM) reference ranges are lacking for Asian populations.
  • Accurate BTMs are vital for osteoporosis diagnosis and monitoring.

Purpose of the Study:

  • To develop a regional BTM reference database for five ASEAN countries.
  • To establish reference intervals for serum Procollagen 1 N-Terminal Propeptide (P1NP), Osteocalcin (OC), and Beta-Crosslaps (CTX).
  • To provide a foundation for osteoporosis management in Southeast Asia.

Main Methods:

  • Combined country-specific data from Malaysia, Philippines, Singapore, Thailand, and Vietnam.
  • Analyzed 746 healthy premenopausal women aged 20-44 years.
  • Measured P1NP, OC, and CTX using automated immunoassay systems.

    • Main Results:

    • Established reference intervals: CTX (128-811 ng/L), OC (9.0-33.0 μg/L), P1NP (22.8-96.5 μg/L).
    • Excluding 20s: CTX (117-678 ng/L), P1NP (21.6-85.8 μg/L), OC (3.5-27.0 μg/L).
    • Observed inter-country variations and decreased BTMs with age after 30.

    Conclusions:

    • This study presents the first BTM reference intervals for healthy premenopausal Southeast Asian women.
    • These intervals are essential for accurate bone turnover assessment in the region.
    • Contributes to improved osteoporosis evaluation and patient monitoring.