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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: Jun 8, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

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Updates in preimplantation genetic testing (PGT).

Sarah Petch1, David Crosby1

  • 1Merrion Fertility Clinic, National Maternity Hospital, Dublin, Ireland; University College, Dublin, Ireland.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|June 30, 2024
PubMed
Summary
This summary is machine-generated.

Preimplantation genetic testing (PGT) analyzes early embryos from IVF/ICSI to select the best one for transfer. This technology reduces inherited disease risks and may improve implantation success.

Keywords:
Assisted human reproductionEmbryo selectionIn vitro fertilisation (IVF)Next generation sequencingPreimplantation genetic testing (PGT)Trophectoderm biopsy

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Embryology

Background:

  • Preimplantation genetic testing (PGT) is a technique used in assisted human reproduction (AHR).
  • It involves genetic analysis of embryos created via in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
  • Initially experimental, PGT is now a standard procedure.

Purpose of the Study:

  • To provide a historical overview of PGT development.
  • To review current evidence supporting PGT applications.
  • To highlight emerging research and future directions in PGT technology.

Main Methods:

  • Review of historical data and published literature on PGT.
  • Analysis of current clinical evidence for PGT efficacy.
  • Identification of key research areas for technological advancement.

Main Results:

  • PGT has evolved significantly since the 1990s, becoming integral to AHR.
  • Embryo selection via PGT can decrease the transmission of inherited disorders.
  • PGT may also reduce rates of implantation failure and pregnancy loss.

Conclusions:

  • PGT is a rapidly advancing field with significant clinical impact.
  • Ongoing research aims to further enhance PGT capabilities.
  • Ethical considerations remain an important aspect of PGT development and application.