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  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Veterinary Sciences
  9. Veterinary Medicine (excl. Urology)
  11. Forelimb Lameness Caused By Malignant Peripheral Nerve Sheath Tumors Of The Median Nerve In A Dog: A Case Report.
  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Veterinary Sciences
  9. Veterinary Medicine (excl. Urology)
  11. Forelimb Lameness Caused By Malignant Peripheral Nerve Sheath Tumors Of The Median Nerve In A Dog: A Case Report.

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Forelimb lameness caused by malignant peripheral nerve sheath tumors of the median nerve in a dog: a case report.

Noriyuki Miyaho1, Manabu Mochizuki1,2, Muneki Honnami1

  • 1Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

The Journal of Veterinary Medical Science
|June 30, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

A Portuguese Water Dog with malignant peripheral nerve sheath tumors (MPNST) experienced temporary relief after neurotomy, but recurrence led to amputation and eventual metastasis. Caution is advised for this surgical approach in canine MPNST cases.

Keywords:
forelimb lamenessmalignant peripheral nerve sheath tumormedian nerveneurotomy

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Area of Science:

  • Veterinary Neurology
  • Canine Oncology
  • Surgical Oncology

Background:

  • Malignant peripheral nerve sheath tumors (MPNST) are rare but aggressive neoplasms affecting peripheral nerves.
  • Early and accurate diagnosis of MPNST in dogs can be challenging, impacting treatment decisions.
  • Surgical intervention, such as neurotomy, is a potential treatment option for localized nerve tumors.

Observation:

  • An 8-year-old Portuguese Water Dog presented with chronic left forelimb lameness and palmar pain.
  • Ultrasonography and MRI revealed significant enlargement of the left median nerve, suggestive of a neoplastic process.
  • Intraoperative findings indicated a likely diagnosis of MPNST.

Findings:

  • A neurotomy was performed, resulting in near-complete resolution of lameness within one month.
ultrasonography
  • Tumor recurrence was observed 26 months post-surgery, necessitating limb amputation.
  • Metastasis to the lungs was confirmed 950 days after the initial neurotomy, with the dog succumbing 988 days post-surgery.

    • Implications:

    • Neurotomy for canine MPNST requires careful consideration due to the risk of recurrence and metastasis.
    • Further research is needed to establish optimal methods for early MPNST detection, margin assessment, and surgical indication in veterinary patients.
    • This case highlights the aggressive nature of MPNST and the limitations of neurotomy as a sole curative treatment.